Endocrine Abstracts

A 49 year old gentleman was diagnosed with a pituitary macroprolactinoma at Leicester Royal Infirmary (LRI) (Baseline prolactin 8000 mU/l). He was treated with Cabergoline 0.5 mg twice/week. He developed CSF rhinorrhoea shortly after treatment was commenced and was listed for repair under the neurosurgical team at Queen’s Medical Centre (QMC). Six weeks later, while visiting Wales, he was admitted to Bangor hospital with headaches and vomiting. CSF cultures were positive ...

Introduction: Turner Syndrome is a chromosomal disorder that is characterized by short stature and gonadal dysgenesis, affecting 1 in 2500 female live births. It is associated with a wide variety of conditions that could lead to significant morbidity and mortality if not followed up and managed appropriately. A multidisciplinary approach is important in the management of these patients. This audit aims to review the current practice of a specialist Turners Syndrome clinic in a...

A 57-year-old gentleman presented with bilateral painless submandibular swelling, and flu like symptoms. A biopsy from the enlarged submandibular gland showed chronic sclerosing sialadenitis with lymphocytic infiltration. Immunohistochemistry showed plasma cells positive for CD79a and IgG4, and a combination of CD4 and CD8 positive lymphocytes. IgG4 levels were significantly raised (3.16 g/l, NR <1.3 g/l). A diagnosis of IgG4 syndrome was made. Chest and abdominal CT imagi...

Introduction: Guidelines for the use of GH in GH deficient adults were issued by the UK National Institute for Clinical Excellence (NICE). To assess current practice in relation to these guidelines, a review of patients receiving GH treatment was performed. The aims were to i) assess if adults with GH deficiency met NICE criteria for GH therapy and ii) identify reasons for initiating or continuing GH treatment if NICE criteria were not met.Methods: Retro...